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Article

Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cells

7 May 2012

Abstract excerpt

Temozolomide (TMZ) is an alkylating chemotherapeutic agent that prolongs the survival of patients with glioblastoma. Clinical benefit is more prominent in patients with methylation of the O(6) -methyl-guanine DNA methyltransferase (MGMT) promoter. However, all patients eventually suffer from tumor progression because their tumors become resistant to TMZ. Here, we modeled acquired TMZ resistance in glioma cells in...

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PMID: 22564186
DOI: 10.1111/j.1471-4159.2012.07781.x

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