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PARP Inhibitor Counteracts Temozolomide Resistance in Glioblastoma Multiforme

2024-12-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Glioblastoma multiforme (GBM) is the most common malignant primary brain tumour in adults and is invariably associated with poor prognosis. Resistance to Temozolomide (TMZ), the standard chemotherapeutic agent, remains a major clinical challenge, particularly due to DNA mismatch repair (MMR) deficiencies. The aim of this study was to determine whether combining TMZ with the...

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Literature Corpus work
fe169033-2230-5664-84c4-9046e4b065a3
DOI
10.1101/2024.12.13.627927
Open publication

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PARP Inhibitor Counteracts Temozolomide Resistance in Glioblastoma MultiformeDOI 10.1101/2024.12.13.627927
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