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Insulin regulates human pancreatic endocrine cell differentiation in vitro

14 Dec 2023

Abstract excerpt

OBJECTIVE: The consequences of mutations in genes associated with monogenic forms of diabetes on human pancreas development cannot be studied in a time-resolved fashion in vivo. More specifically, if recessive mutations in the insulin gene influence human pancreatic endocrine lineage formation is still an unresolved question. METHODS: To model the extremely reduced insulin levels in patients with recessive...

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PMID: 38103636
DOI: 10.1016/j.molmet.2023.101853

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