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Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation.

Stem cell reports - 10 Oct 2017

Petersen Maja Borup Kjær, Azad Ajuna, Ingvorsen Camilla, Hess Katja, Hansson Mattias, Grapin-Botton Anne, Honoré Christian

Abstract excerpt

The production of insulin-producing β cells from human embryonic stem cells (hESCs) in vitro represents a promising strategy for a cell-based therapy for type 1 diabetes mellitus. To explore the cellular heterogeneity and temporal progression of endocrine progenitors and their progeny, we performed single-cell qPCR on more than 500 cells across several stages of in vitro differentiation of hESCs and compared them...

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Basic Helix-Loop-Helix Transcription Factors
Cell Lineage
Embryonic Stem Cells
Genes, Reporter
Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin-Secreting Cells

Single-Cell Analysis

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PMID: 28919263
DOI: 10.1016/j.stemcr.2017.08.009
PMCID: PMC5639261

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