Seven complete comparative maps of allosteric mutations in a protein family.

Abstract excerpt

Long-range communication in proteins is key to biological regulation and the efficacy of many drugs. However, the extent to which indirect energetic couplings between distant sites are conserved in homologous proteins during evolution is largely unknown. Here we directly address this question by constructing seven comprehensive maps of how mutations throughout five homologous human PDZ domains directly and...

Topics

• Humans
• Mutation
• Allosteric Regulation
• PDZ Domains
• Protein Binding
• Proteins
• Models, Molecular
• Ligands
• Binding Sites
• Thermodynamics