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Article

An expanded view of the protein folding landscape of PDZ domains.

Biochemical and biophysical research communications - 11 May 2012

Hultqvist Greta, Pedersen Søren W, Chi Celestine N, Strømgaard Kristian, Gianni Stefano, Jemth Per

Abstract excerpt

Most protein domains fold in an apparently co-operative and two-state manner with only the native and denatured states significantly populated at any experimental condition. However, the protein folding energy landscape is often rugged and different transition states may be rate limiting for the folding reaction under different conditions, as seen for the PDZ protein domain family. We have here analyzed the...

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PMID: 22521641
DOI: 10.1016/j.bbrc.2012.04.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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