Article

Mega-scale experimental analysis of protein folding stability in biology and protein design

2022-12-06

Abstract excerpt

Advances in DNA sequencing and machine learning are illuminating protein sequences and structures on an enormous scale. However, the energetics driving folding are invisible in these structures and remain largely unknown. The hidden thermodynamics of folding can drive disease, shape protein evolution, and guide protein engineering, and new approaches are needed to reveal these thermodynamics for every sequence and...

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Literature Corpus work: dfc6c9a0-3b0d-56f4-8b64-a7806ce80993
DOI: 10.1101/2022.12.06.519132

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