Article

Mutation-induced reshaping of protein conformational dynamics revealed by a coarse-grained modeling framework

2026-03-31

Abstract excerpt

Disease-related missense mutations reshape protein conformational energy landscapes, thereby altering biological function. However, mechanistically linking sequence variation to changes in conformational dynamics remains challenging for both experimental and computational approaches. Here, we introduce an internal-coordinate-based, essential-dynamics-refined elastic network model (ICed-ENM) that improves the physi...

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Literature Corpus work: 590a2f6b-419f-5ba3-ae83-c46c23d2c30a
DOI: 10.64898/2026.03.29.715126

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