Article

Huntingtin is essential for synaptic plasticity in the adult hippocampus

2022-10-05

Abstract excerpt

Huntingtin (HTT), an exceptionally large protein with hundreds of interacting partners within the central nervous system, has been extensively studied due to its role in Huntington’s disease (HD) pathology. HD is a monogenic disorder caused by a polyglutamine repeat expansion in the HTT gene, which results in the production of a pathogenic mutant huntingtin (mHTT) protein, and toxic effects of this mutant protein...

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Literature Corpus work: 4a9a0254-bad2-54c4-a840-0ea660467cc9
DOI: 10.1101/2022.10.05.510980

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