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BDNF and TRiC-inspired reagent rescue cortical synaptic deficits in a mouse model of Huntington's disease

10 Apr 2024

Abstract excerpt

Synaptic changes are early manifestations of neuronal dysfunction in Huntington's disease (HD). However, the mechanisms by which mutant HTT protein impacts synaptogenesis and function are not well understood. Herein we explored HD pathogenesis in the BACHD mouse model by examining synaptogenesis and function in long term primary cortical cultures. At DIV14 (days in vitro), BACHD cortical neurons showed no...

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PMID: 38608784
DOI: 10.1016/j.nbd.2024.106502

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