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Article

Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits

9 Jul 2014

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a poly-glutamine (poly-Q) stretch in the huntingtin (Htt) protein. Gain-of-function effects of mutant Htt have been extensively investigated as the major driver of neurodegeneration in HD. However, loss-of-function effects of poly-Q mutations recently emerged as potential drivers of disease pathophysiology. Early synaptic problems...

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PMID: 25009276
DOI: 10.1523/jneurosci.4699-13.2014

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