Article

BDNF and TRiC-inspired Reagents Rescue Cortical Synaptic Deficits in a Mouse Model of Huntington’s Disease

2022-11-25

Abstract excerpt

Huntington’s disease (HD) results from a CAG repeat expansion in the gene for Huntington (HTT) resulting in expansion of the polyglutamine (Q) tract in the mutant protein (mHTT). Synaptic changes are early manifestations of neuronal dysfunction in HD. However, the mechanism(s) by which mHTT impacts synapse formation and function is not well defined. Herein we explored HD pathogenesis in the BACHD and the ΔN17-BACH...

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Literature Corpus work: 77dc2334-1e77-57ff-ace5-6699a3bee49e
DOI: 10.1101/2022.11.25.517123

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