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Article

Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.

The Journal of cell biology - 30 Sept 2013

Xu Qiaoqiao, Huang Shanshan, Song Mingke, Wang Chuan-En, Yan Sen, Liu Xudong, Gaertig Marta A, Yu Shan Ping, Li He, Li Shihua, Li Xiao-Jiang

Abstract excerpt

Many genetic mouse models of Huntington's disease (HD) have established that mutant huntingtin (htt) accumulates in various subcellular regions to affect a variety of cellular functions, but whether and how synaptic mutant htt directly mediates HD neuropathology remains to be determined. We generated transgenic mice that selectively express mutant htt in the presynaptic terminals. Although it was not...

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Identifiers

PMID: 24081492
DOI: 10.1083/jcb.201303146
PMCID: PMC3787372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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