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Article

Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease.

Human molecular genetics - 15 May 2006

Milnerwood Austen J, Cummings Damian M, Dallérac Glenn M, Brown Jacki Y, Vatsavayai Sarat C, Hirst Mark C, Rezaie Payam, Murphy Kerry P S J

Abstract excerpt

Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor, psychiatric and cognitive decline. Marked neuronal loss occurs in the cortex and striatum. HD is inherited in an autosomal dominant fashion and caused by a trinucleotide repeat expansion (CAG) in the gene encoding the protein huntingtin. Predictive genetic testing has revealed early cognitive deficits in...

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Identifiers

PMID: 16600988
DOI: 10.1093/hmg/ddl092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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