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Article

Plk1 overexpression induces chromosomal instability and suppresses tumor development

26 Jul 2018

Abstract excerpt

Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors, being frequently considered as an oncogene and an attractive cancer target. However, its contribution to tumor development is unclear. Using a new inducible knock-in mouse model we report here that Plk1 overexpression results in abnormal chromosome segregation and cytokinesis, generating polyploid cells with reduced proliferative...

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PMID: 30069007
DOI: 10.1038/s41467-018-05429-5

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