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Article

CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer

14 Aug 2018

Abstract excerpt

Abstract The centrosomal protein, CEP55, is a key regulator of cytokinesis, and its overexpression is linked to genomic instability, a hallmark of cancer. However, the mechanism by which it mediates genomic instability remains elusive. Here, we showed that CEP55 overexpression/knockdown impacts survival of aneuploid cells. Loss of CEP55 sensitizes breast cancer cells to anti‐mitotic agents through premature...

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PMID: 30108112
DOI: 10.15252/emmm.201708566

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