Article

Rejuvenation strategies share gene expression programs of reduced inflammation and downstream restored fatty acid metabolism

2022-09-27

Abstract excerpt

Understanding the mechanism of rejuvenation is central to aging research. No study has compared the effects of the four major rejuvenation strategies: senolytics, caloric restriction, in vivo partial cellular reprogramming and young/old blood factor exchange, which operate via different modalities. We use mice transcriptional data to compare them to each other and to normal aging. We find a shared gene expression...

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Literature Corpus work: 4a744765-1bc5-53a5-9df1-79675eb51292
DOI: 10.1101/2022.09.26.509471

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