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Heterochronic parabiosis uncovers AdipoR1 as a critical player in retinal rejuvenation

16 Jul 2025

Abstract excerpt

Aging induces substantial structural and functional decline in the retina, yet the molecular drivers of this process remain elusive. In this study, we used heterochronic parabiosis (HP) combined with single-cell RNA sequencing to generate comprehensive transcriptomic profiles of murine retinas from young, aged, and HP pairs, aiming to identify antiaging targets. Our analysis revealed extensive transcriptional...

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PMID: 40668916
DOI: 10.1126/sciadv.adv6642

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