Article
Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identity
2022-12-14
Abstract excerpt
Partial somatic cell reprogramming has been touted as a promising rejuvenation strategy. However, its association with mechanisms of aging and longevity at the molecular level remains unclear. We identified a robust transcriptomic signature of reprogramming in mouse and human cells that revealed co-regulation of genes associated with reprogramming and response to lifespan-extending interventions, including those r...
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Identifiers and source
- Literature Corpus work
- d5b9900d-d25a-5233-bf35-03788253f686
- DOI
- 10.1101/2022.12.12.520058