Article

A pan-cancer analysis of matrisome proteins reveals CTHRC1and LOXL2 as major ECM regulators across cancers

2021-04-28

Abstract excerpt

The extracellular matrix as part of the tumor microenvironment can regulate cancer cell growth and progression. Using TCGA data from 30 cancer types, the top 5% of matrisome genes with amplifications or deletions that affect survival in cancers were identified. Eight of these genes show altered expression in ~50% or more cancers affecting survival in ~20% or more. Among them SNED1 is the most downregulated and CTH...

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Literature Corpus work: 8a7c8c1d-bd48-5147-97e6-e7fbe6b5a7af
DOI: 10.1101/2021.04.27.441627

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