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Proteomic Characterization of KRAS Mutation Landscapes in Lung Adenocarcinoma: A Multi-Algorithm Machine Learning Framework Identifies MUC5AC-Mediated Immune-Inflammatory Reprogramming

2026-05-08

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> KRAS mutation is a primary driver in lung adenocarcinoma (LUAD), significantly influencing tumor biology and the microenvironment. While genomic profiling is standard, characterizing the dynamic proteomic landscape is essential for identifying stable diagnostic markers and therapeutic vulnerabilities. This study aims to construct a high-fidelity diagnostic mo...

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Literature Corpus work
6395616a-1b8b-5dc1-907c-f1cd323cee26
DOI
10.21203/rs.3.rs-9643718/v1
Open publication

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Proteomic Characterization of KRAS Mutation Landscapes in Lung Adenocarcinoma: A Multi-Algorithm Machine Learning Framework Identifies MUC5AC-Mediated Immune-Inflammatory ReprogrammingDOI 10.21203/rs.3.rs-9643718/v1
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