Integrated whole-exome and bulk transcriptome sequencing delineates the dynamic evolution from preneoplasia to invasive lung adenocarcinoma featured with ground-glass nodules.

doi:10.1002/cam4.7383

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Integrated whole-exome and bulk transcriptome sequencing delineates the dynamic evolution from preneoplasia to invasive lung adenocarcinoma featured with ground-glass nodules.

Cancer medicine - 1 Jun 2024

Zhou Dong, Li Yan-Qi, Liu Quan-Xing, Deng Xu-Feng, Chen Liang, Li Man-Yuan, Zhang Jiao, Lu Xiao, Zheng Hong, Dai Ji-Gang

Abstract excerpt

OBJECTIVE: The genomic and molecular ecology involved in the stepwise continuum progression of lung adenocarcinoma (LUAD) from adenocarcinoma in situ (AIS) to minimally invasive adenocarcinoma (MIA) and subsequent invasive adenocarcinoma (IAC) remains unclear and requires further elucidation. We aimed to characterize gene mutations and expression landscapes, and explore the association between differentially...

Topics

Humans
Exome Sequencing
Adenocarcinoma of Lung
Lung Neoplasms
Male
Female
Mutation
Middle Aged
Aged
Neoplasm Invasiveness
Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Transcriptome

Gene Expression Profiling

Adenocarcinoma in Situ

Precancerous Conditions

Biomarkers, Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 38864483
DOI: 10.1002/cam4.7383
PMCID: PMC11167609

Genes

EGFR
RBM10
ADAMTS16
CCR9
DEPTOR
GPR143
MAL2
MIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated whole-exome and bulk transcriptome sequencing delineates the dynamic evolution from preneoplasia to invasive lung adenocarcinoma featured with ground-glass nodules.PMID 38864483Read ↗

Differences of molecular events driving pathological and radiological progression of lung adenocarcinoma.Semantic proximity Read ↗

Genomic and Transcriptomic Dynamics in the Stepwise Progression of Lung AdenocarcinomaSemantic proximity Read ↗

Single-cell transcriptome atlas of lung adenocarcinoma featured with ground glass nodulesSemantic proximity Read ↗

Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma.Semantic proximity Read ↗

Genomic signature driving preinvasive to invasive processes in stage I lung adenocarcinoma.Semantic proximity Read ↗

Mechanisms of Progression and Heterogeneity in Multiple Nodules of Lung AdenocarcinomaSemantic proximity Read ↗

Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesionsSemantic proximity Read ↗

Up-regulated tumor intrinsic growth potential and decreased immune function orchestrate the evolution of lung adenocarcinomaSemantic proximity Read ↗

Single‐cell RNA sequencing reveals the multi‐cellular ecosystem in different radiological components of pulmonary part‐solid nodulesSemantic proximity Read ↗

Deep sequencing reveals the genomic characteristics of lung adenocarcinoma presenting as ground-glass nodules (GGNs)Semantic proximity Read ↗

Multicellular ecotypes shape progression of lung adenocarcinoma from ground-glass opacity toward advanced stagesSemantic proximity Read ↗

Evolutionary proteogenomic landscape from pre-invasive to invasive lung adenocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.