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Article

Multi-omics analyses reveal distinct molecular characteristics and transformation mechanisms of stage I-III micropapillary lung adenocarcinoma.

The Journal of pathology - 1 Jun 2025

Qu Yang, Feng Xiaoli, Chen Hanlin, Tan Fengwei, Shao Anqi, Pang Jiaohui, Xue Qi, Zheng Bo, Zheng Wei, Ou Qiuxiang, Gao Shugeng, Shao Kang

Abstract excerpt

The micropapillary (MIP) pattern is a high-grade histological subtype of lung adenocarcinoma (LUAD) with poor prognosis. In this study, surgically resected tumor samples from 101 patients with stage I-III MIP-LUAD (MIP ≥30%) were microdissected to separate MIP components from non-MIP components, all of which underwent RNA and DNA whole-exome sequencing (WES). The genomic and transcriptomic landscapes of MIP and...

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Topics

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40151900
DOI: 10.1002/path.6416

Genes

MIP
EGFR
ADGRV1
CDKN2A
CDKN2B
MACF1
PCLO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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