Article

<i>Ab-initio</i> discovery of tumoricidal oligonucleotides in a DNA sequencing machine

2019-05-07

Abstract excerpt

We describe a technique for the rapid ab-initio discovery of target-tailored tumoricidal DNA oligonucleotides inside an Illumina sequencing chip. By sequencing oligonucleotide pools we generate a physical microfluidic map of hundreds of millions of potential oligo clusters, in which every cluster is mapped to a specific set of spatial coordinates. Tumor cells, pre-loaded with a fluorogenic reporter of apoptosis,...

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Literature Corpus work: 4a27580b-db6c-53ae-8419-730f6bec406c
DOI: 10.1101/630830

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