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Article

Microarray-based multicycle-enrichment of genomic subsets for targeted next-generation sequencing.

Genome research - 1 Sept 2009

Summerer Daniel, Wu Haiguo, Haase Bettina, Cheng Yang, Schracke Nadine, Stähler Cord F, Chee Mark S, Stähler Peer F, Beier Markus

Abstract excerpt

The lack of efficient high-throughput methods for enrichment of specific sequences from genomic DNA represents a key bottleneck in exploiting the enormous potential of next-generation sequencers. Such methods would allow for a systematic and targeted analysis of relevant genomic regions. Recent studies reported sequence enrichment using a hybridization step to specific DNA capture probes as a possible solution to...

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PMID: 19638418
DOI: 10.1101/gr.091942.109
PMCID: PMC2752126

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BRCA1

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