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OPENchip: an on-chip in situ molecular profiling platform for gene expression analysis and oncogenic mutation detection in single circulating tumour cells.

Lab on a chip - 3 Mar 2020

Lee Amos C, Svedlund Jessica, Darai Evangelia, Lee Yongju, Lee Daewon, Lee Han-Byoel, Kim Sung-Min, Kim Okju, Bae Hyung Jong, Choi Ahyoun, Lee Sumin, Jeong Yunjin, Song Seo Woo, Choi Yeongjae, Yeom Huiran, Lee Caleb S, Han Wonshik, Lee Dong Soon, Jang Jin-Young, Madaboosi Narayanan, Nilsson Mats, Kwon Sunghoon

Abstract excerpt

Liquid biopsy holds promise towards practical implementation of personalized theranostics of cancer. In particular, circulating tumour cells (CTCs) can provide clinically actionable information that can be directly linked to prognosis or therapy decisions. In this study, gene expression patterns and genetic mutations in single CTCs are simultaneously analysed by strategically combining microfluidic technology and...

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PMID: 32057051
DOI: 10.1039/c9lc01248f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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