Article

Combi-Seq: Multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell droplets

2021-09-17

Abstract excerpt

Anti-cancer therapies often exhibit only short-term effects. Tumors typically develop drug resistance causing relapses that might be tackled with drug combinations. Identification of the right combination is challenging and would benefit from high-content, high-throughput combinatorial screens directly on patient biopsies. However, such screens require a large amount of material, normally not available from patien...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 47f82dfe-6d96-5ba6-baf6-6814310b0497
DOI: 10.1101/2021.09.16.460212

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combi-Seq: Multiplexed transcriptome-based profiling of drug combinations using deterministic barcoding in single-cell dropletsDOI 10.1101/2021.09.16.460212Read

Combinatorial perturbation sequencing on single cells using microwell-based droplet random pairingSemantic proximity Read

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action.Semantic proximity Read

Quantitative and multiplexed chemical-genetic phenotyping in mammalian cells with QMAP-Seq.Semantic proximity Read

Local generation and efficient evaluation of numerous drug combinations in a single sample.Semantic proximity Read

Personalized tumor combination therapy optimization using the single-cell transcriptomeSemantic proximity Read

QMAP-Seq: Quantitative and Multiplexed Analysis of Phenotype by SequencingSemantic proximity Read

Perturbational Gene-Expression Signatures for Combinatorial Drug DiscoverySemantic proximity Read

Grouped-seq for integrated phenotypic and transcriptomic screening of patient-derived tumor organoids.Semantic proximity Read

Patient-tailored design of AML cell subpopulation-selective drug combinationsSemantic proximity Read

Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimensSemantic proximity Read

Predicting drug response from single-cell expression profiles of tumoursSemantic proximity Read

Simultaneous DNA, RNA, and Protein Analysis from Single Cells Using a High-Throughput Microfluidic Workflow for Resolution of Genotype-to-Phenotype Modalities.Semantic proximity Read