Article

High-throughput screening of functional neo-antigens and their specific TCRs via the Jurkat reporter system combined with droplet microfluidics

2023-02-21

Abstract excerpt

<h4>Summary</h4> T-cell receptor (TCR)-engineered T cells can precisely recognize a broad repertoire of targets derived from both intracellular and surface proteins of tumor cells. TCR-T adoptive cell therapy has shown safety and promising efficacy in solid tumor immunotherapy. However, antigen-specific functional TCR screening is time-consuming and expensive, which limits its application clinically. Here, we dev...

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Literature Corpus work: 50f439ae-8066-5893-bad4-caec134b11f9
DOI: 10.1101/2023.02.20.529171

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