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Article

Rapid Screening of Peptide Probes through <i>In Situ</i> Single-Bead Sequencing Microarray

5 Nov 2014

Abstract excerpt

Peptide ligands as targeting probes for in vivo imaging and drug delivery have attracted great interest in the biomedical community. However, high affinity and specificity screening of large peptide libraries remains a tedious process. Here, we report a continuous-flow microfluidic method for one-bead-one-compound (OBOC) combinatorial peptide library screening. We screened a library with 2 × 10(5) peptide beads...

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PMID: 25370073
DOI: 10.1021/ac503454z

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