Article
Stem Cell DNA Damage and Genome Mutation in the Context of Aging and Cancer Initiation.
Cold Spring Harbor perspectives in biology - 1 Oct 2020
Al Zouabi Lara, Bardin Allison J
Abstract excerpt
Adult stem cells fuel tissue homeostasis and regeneration through their unique ability to self-renew and differentiate into specialized cells. Thus, their DNA provides instructions that impact the tissue as a whole. Since DNA is not an inert molecule, but rather dynamic, interacting with a myriad of chemical and physical factors, it encounters damage from both endogenous and exogenous sources. Damage to DNA...
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