Article

A novel approach to evaluate alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy

2021-08-10

Abstract excerpt

Several in vitro and in vivo findings have consistently shown that α-synuclein derived from multiple system atrophy (MSA) subjects has more seeding capacity than Parkinson’s disease-derived α-synuclein. However, reliable detection of α-synuclein derived from MSA using seeded amplification assays, such as the Real-Time Quaking-induced Conversion, has remained challenging. Here we demonstrate that the interaction...

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Literature Corpus work: 273e4b6f-419f-58a1-a4f0-a224dd4a0e13
DOI: 10.1101/2021.08.10.455800

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