Tauopathy strains differentially replicate in vitro in the presence of mutant tau monomer.

Abstract excerpt

Tauopathies are a group of neurodegenerative diseases caused by misfolding of the protein tau into a β-sheet rich conformation. By inducing misfolding of additional tau monomers, these pathogenic fibrils replicate and spread progressive disease throughout the brain. While frontotemporal lobar degenerative diseases (FTLDs) - including argyrophilic grain disease, corticobasal degeneration, globular glial tauopathy,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Mice
• Share to Mutation
• Share to tau Proteins