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Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains

19 Dec 2022

Abstract excerpt

Tau aggregation associates with multiple neurodegenerative diseases including Alzheimer's disease and rare tauopathies such as Pick's disease, progressive supranuclear palsy, and corticobasal degeneration. The molecular and structural basis of tau aggregation and related diverse misfolded tau strains are not fully understood. To further understand tau-protein aggregation mechanisms, we performed systematic...

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PMID: 36558893
DOI: 10.3390/pathogens11121559

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