Article

A Spider Silk-derived Solubility Domain Inhibits Nuclear and Cytosolic Protein Aggregation in Human Cells

2021-10-29

Abstract excerpt

Due to the inherent toxicity of protein aggregates, the propensity of natural, functional amyloidogenic proteins to aggregate must be tightly controlled to avoid negative consequences on cellular viability. The importance of controlled aggregation in biological processes is illustrated by spidroins, which are functional amyloidogenic proteins that form the basis for spider silk. Premature aggregation of spidroins...

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Literature Corpus work: 49b061ca-2db3-5a48-9e1d-b0646c1a14cb
DOI: 10.21203/rs.3.rs-990691/v1

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