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Article

Modelling FUSopathies: focus on protein aggregation

20 Nov 2013

Abstract excerpt

The discovery of a causative link between dysfunction of a number of RNA-binding proteins with prion-like domains and the development of certain (neuro)degenerative diseases has completely changed our perception of molecular mechanisms instigating pathological process in these disorders. Irreversible aggregation of these proteins is a crucial pathogenic event delineating a type of proteinopathy. FUS (fused in...

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PMID: 24256263
DOI: 10.1042/bst20130212

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