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Article

Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.

Human molecular genetics - 15 Apr 2018

Matsumoto Taisei, Matsukawa Koji, Watanabe Naruaki, Kishino Yuya, Kunugi Hayato, Ihara Ryoko, Wakabayashi Tomoko, Hashimoto Tadafumi, Iwatsubo Takeshi

Abstract excerpt

Aggregation of fused in sarcoma (FUS) protein, and mutations in FUS gene, are causative to a range of neurodegenerative disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. To gain insights into the molecular mechanism whereby FUS causes neurodegeneration, we generated transgenic Drosophila melanogaster overexpressing human FUS in the photoreceptor neurons, which exhibited mild...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29425337
DOI: 10.1093/hmg/ddy046

Genes

FUS

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Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.PMID 29425337Read ↗

Expression of human FUS protein in Drosophila leads to progressive neurodegeneration.Semantic proximity Read ↗

Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashionSemantic proximity Read ↗

Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative DiseasesSemantic proximity Read ↗

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.Semantic proximity Read ↗

Importance of Functional Loss of FUS in FTLD/ALSSemantic proximity Read ↗

Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis.Semantic proximity Read ↗

ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism.Semantic proximity Read ↗

Animal Models of FUS-Proteinopathy: A Systematic Review.Semantic proximity Read ↗

Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.Semantic proximity Read ↗

FUS-induced neurotoxicity is prevented by inhibiting GSK-3β in a Drosophila model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

FUS-related proteinopathies: Lessons from animal modelsSemantic proximity Read ↗

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