Article
The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2.
Biochemical and biophysical research communications - 10 Sept 2021
Shimakura Kento, Sato Kai, Mitsui Shun, Ono Suzuka, Otomo Asako, Hadano Shinji
Abstract excerpt
ALS2, a product of the causative gene for familial amyotrophic lateral sclerosis (ALS) type 2, plays a pivotal role in the regulation of endosome dynamics by activating small GTPase Rab5 via its intrinsic guanine nucleotide-exchange factor activity. Previously, we have reported that the N-terminal region of ALS2 has crucial roles in its endosomal localization and self-oligomerization, both of which are...
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