Article

Aβ-targeting synNotch Receptor for Alzheimer’s Disease: Expanding Applications to Extracellular Protein Aggregates

2024-10-17

Abstract excerpt

<h4>Summary</h4> The synthetic Notch receptor (synNotch) system is a versatile platform that induces gene transcription in response to extracellular signals. However, its application has been largely confined to membrane-bound targets due to specific activation requirements. Whether synNotch can also target extracellular protein aggregates, such as amyloid beta (Aβ) in Alzheimer’s disease (AD), is unclear. To add...

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Literature Corpus work: b5bec13f-bf4e-58d0-9529-a85017514739
DOI: 10.1101/2024.10.15.618096

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