Article

Markovian State Models uncover Casein Kinase 1 dynamics that govern circadian period

2025-01-22

Abstract excerpt

Circadian rhythms in mammals are tightly regulated through phosphorylation of Period (PER) proteins by Casein Kinase 1 (CK1, subtypes δ and ε). CK1 acts on at least two different regions of PER with opposing effects: phosphorylation of phosphodegron (pD) regions leads to PER degradation, while phosphorylation of the Familial Advanced Sleep Phase (FASP) region leads to PER stabilization. To investigate how substrat...

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Literature Corpus work: 2af62f1e-b4e1-558d-adab-b942b25e2eec
DOI: 10.1101/2025.01.17.633651

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