Article

Partner-independent fusion gene detection by multiplexed CRISPR/Cas9 enrichment and long-read Nanopore sequencing

2019-10-17

Abstract excerpt

Fusion genes are hallmarks of various cancer types and important determinants for diagnosis, prognosis and treatment possibilities. The promiscuity of fusion genes with respect to partner choice and exact breakpoint-positions restricts their detection in the diagnostic setting, even for known and recurrent fusion gene configurations. To accurately identify these gene fusions in an unbiased manner, we developed FUD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4991339b-9dd9-531e-94a4-768d945de3b5
DOI: 10.1101/807545

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Partner-independent fusion gene detection by multiplexed CRISPR/Cas9 enrichment and long-read Nanopore sequencingDOI 10.1101/807545Read

Rapid detection of myeloid neoplasm fusions using Single Molecule Long-Read SequencingSemantic proximity Read

JAFFAL: Detecting fusion genes with long read transcriptome sequencingSemantic proximity Read

Fusion genes and their discovery using high throughput sequencing.Semantic proximity Read

Identification and functional characterisation of gene fusions in human cancer cell linesSemantic proximity Read

Validation of a Targeted RNA Sequencing Assay for Kinase Fusion Detection in Solid Tumors.Semantic proximity Read

JuLI: accurate detection of DNA fusions in clinical sequencing for precision oncologySemantic proximity Read

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR/Cas9 screeningSemantic proximity Read

Discovery of Clinically Relevant Fusions in Pediatric CancerSemantic proximity Read

Comprehensive genome and transcriptome analysis reveals genetic basis for gene fusions in cancerSemantic proximity Read

<b>FusionCatcher</b> – a tool for finding somatic fusion genes in paired-end RNA-sequencing dataSemantic proximity Read

Improved detection of gene fusions by applying statistical methods reveals new oncogenic RNA cancer driversSemantic proximity Read

The emerging complexity of gene fusions in cancer.Semantic proximity Read