Article
Validation of a Targeted RNA Sequencing Assay for Kinase Fusion Detection in Solid Tumors.
The Journal of molecular diagnostics : JMD - 1 Sept 2017
Reeser Julie W, Martin Dorrelyn, Miya Jharna, Kautto Esko A, Lyon Ezra, Zhu Eliot, Wing Michele R, Smith Amy, Reeder Matthew, Samorodnitsky Eric, Parks Hannah, Naik Karan R, Gozgit Joseph, Nowacki Nicholas, Davies Kurtis D, Varella-Garcia Marileila, Yu Lianbo, Freud Aharon G, Coleman Joshua, Aisner Dara L, Roychowdhury Sameek
Abstract excerpt
Kinase gene fusions are important drivers of oncogenic transformation and can be inhibited with targeted therapies. Clinical grade diagnostics using RNA sequencing to detect gene rearrangements in solid tumors are limited, and the few that are available require prior knowledge of fusion break points. To address this, we have analytically validated a targeted RNA sequencing assay (OSU-SpARKFuse) for fusion...
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