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Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant.

Free radical biology & medicine - 16 Aug 2026

Hernández-Gerez Elena, Goya-Iglesias Nuria, Viedma-Poyatos Álvaro, Pajares María A, Pérez-Sala Dolores

Abstract excerpt

Intermediate filaments are critical regulators of cell responses and organizers of cellular structures. Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that provides structural and functional support to astrocytes. GFAP is a key target of oxidative stress and its expression and assembly are altered in brain disease and injury. Moreover, GFAP mutations can provoke protein aggregation and...

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PMID: 42103165
DOI: 10.1016/j.freeradbiomed.2026.05.280

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GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander disease GFAP R239C mutant.PMID 42103165Read ↗

Lysosomal function, resistance to stress and repair are compromised by expression of the Alexander disease GFAP R239C mutantSemantic proximity Read ↗

Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants.Semantic proximity Read ↗

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Alexander disease: models, mechanisms, and medicine.Semantic proximity Read ↗

Glial fibrillary acidic protein is pathologically modified in Alexander disease.Semantic proximity Read ↗

Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder.Semantic proximity Read ↗

Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease.Semantic proximity Read ↗

Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3.Semantic proximity Read ↗

Astrocytic Reactivity Triggered by defective Mitophagy Activates NF-kB Signaling and Causes Neurotoxicity in Frontotemporal Dementia Type 3Semantic proximity Read ↗

GFAP Mutations in Astrocytes Impair Oligodendrocyte Progenitor Proliferation and Myelination in an hiPSC Model of Alexander Disease.Semantic proximity Read ↗

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