Article

scONE-seq: A one-tube single-cell multi-omics method enables simultaneous dissection of molecular phenotype and genotype heterogeneity from frozen tumors

2021-10-15

Abstract excerpt

<title>Abstract</title> <p>Genomic and transcriptomic heterogeneity both play important roles in normal cellular function as well as in disease development. To be able to characterize these different forms of cellular heterogeneity in diverse sample types, we developed scONE-seq, which enables simultaneous transcriptome and genome profiling in a one-tube reaction. Previous single-cell-whole-genome-RNA-sequencing...

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Literature Corpus work: 5e2ef98e-ee7d-509f-81c0-56b77890ec5c
DOI: 10.21203/rs.3.rs-956200/v2

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