Article
Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia.
PLoS genetics - 1 Jan 2013
Atak Zeynep Kalender, Gianfelici Valentina, Hulselmans Gert, De Keersmaecker Kim, Devasia Arun George, Geerdens Ellen, Mentens Nicole, Chiaretti Sabina, Durinck Kaat, Uyttebroeck Anne, Vandenberghe Peter, Wlodarska Iwona, Cloos Jacqueline, Foà Robin, Speleman Frank, Cools Jan, Aerts Stein
Abstract excerpt
RNA-seq is a promising technology to re-sequence protein coding genes for the identification of single nucleotide variants (SNV), while simultaneously obtaining information on structural variations and gene expression perturbations. We asked whether RNA-seq is suitable for the detection of driver mutations in T-cell acute lymphoblastic leukemia (T-ALL). These leukemias are caused by a combination of gene fusions,...
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