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Closing the fusion-detection gap in single-cell RNA-seq with a scalable, probe-based workflow

2026-08-29

Abstract excerpt

Single-cell RNA-sequencing resolves cellular states in exquisite detail. Yet oncogenic gene fusions, key drivers in 16.5% of malignancies and ~50-70% of acute lymphoblastic leukaemia (ALL) cases, remain largely invisible at this resolution. This leaves a fundamental gap in understanding cancer biology. We close it with synthesis-ready fusion probes designed via our Flexify R package from fusion junction sequences...

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Literature Corpus work: f18a8d78-ee56-54db-bfff-cff80a89f6d8
DOI: 10.64898/2026.08.26.747171

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