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A complete digital karyotype of the B-cell leukemia REH cell line resolved by long-read sequencing

2023-03-10

Abstract excerpt

<h4>ABSTRACT</h4> The B-cell acute lymphoblastic leukemia (ALL) cell line REH, with the t(12;21) ETV6-RUNX1 translocation, is known to have a complex karyotype defined by a series of large-scale chromosomal rearrangements. Taken from a 15-year-old at relapse, the cell line offers a practical model for the study of high-risk pediatric B-ALL patients. In recent years, short-read DNA and RNA sequencing have emerged...

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Literature Corpus work
2785a3e2-8116-53bf-81ea-f8704dc23eeb
DOI
10.1101/2023.03.08.531483
Open publication

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A complete digital karyotype of the B-cell leukemia REH cell line resolved by long-read sequencingDOI 10.1101/2023.03.08.531483
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