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Ubiquitin-Proteasome System Dysregulation in Alzheimer’s Disease Impacts Protein Abundance

2025-05-29

Abstract excerpt

Alzheimer’s disease (AD) is a relentlessly progressive, fatal neurodegenerative disorder that results in widespread protein dysfunctions. However, the full extent of aberrant proteomic changes in AD and their impact remains unknown, in part, because of the challenges of comprehensively measuring the proteome. Here, we used plexDIA, an approach that provides deep proteomic coverage and high throughput by paralleliz...

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Literature Corpus work
49406fc2-4620-5e86-be51-6f0127a1def9
DOI
10.1101/2025.05.29.656728
Open publication

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Ubiquitin-Proteasome System Dysregulation in Alzheimer’s Disease Impacts Protein AbundanceDOI 10.1101/2025.05.29.656728
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