Article

Early Proteasome Gene Downregulation And Impaired Proteasomes Function Underlie Proteostasis Failure In Alzheimer’s Disease

2025-01-24

Abstract excerpt

Alzheimer’s disease (AD) is characterized by the accumulation of pathogenic proteins, notably amyloid-beta and hyperphosphorylated tau, which disrupt neuronal function and contribute to cognitive decline. Although proteotoxic stress is well-established in AD, the role of the ubiquitin-proteasome system (UPS) in maintaining neuronal proteostasis, and how it becomes compromised during disease progression remains inc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f29ab1b-80bc-5a81-8acc-72f4ac4ac8d2
DOI: 10.1101/2025.01.21.634128

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Early Proteasome Gene Downregulation And Impaired Proteasomes Function Underlie Proteostasis Failure In Alzheimer’s DiseaseDOI 10.1101/2025.01.21.634128Read

Ubiquitin-Proteasome System Dysregulation in Alzheimer’s Disease Impacts Protein AbundanceSemantic proximity Read

Protein quality control in Alzheimer's disease by the ubiquitin proteasome system.Semantic proximity Read

Early neuronal reprogramming and cell cycle reentry shape Alzheimer’s disease progressionSemantic proximity Read

Deciphering molecular atlas of Alzheimer’s disease: A comprehensive bioinformatic analysis of gene expression and protein interaction networksSemantic proximity Read

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s diseaseSemantic proximity Read

NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasomeSemantic proximity Read

APOE4 disrupts the central dogma by arresting neuronal proteome dynamicsSemantic proximity Read

Composition and activity of the proteasome in human iPSC-derived neuronal model of early-stage sporadic Alzheimer’s diseaseSemantic proximity Read

Molecular and structural remodeling of stress granules in slowly and rapidly progressive Alzheimer’s diseaseSemantic proximity Read

Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer’s diseaseSemantic proximity Read

Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive declineSemantic proximity Read

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophySemantic proximity Read