Article

Post-translational modifications in the brain are critical contributors to Alzheimer’s disease neuropathology and cognitive decline

2026-06-13

Abstract excerpt

Post-translational modifications (PTMs) in APP and MAPT contribute to plaques and tangles in Alzheimer’s disease (AD). Yet broader proteome-wide PTMs in the AD brain are relatively unexplored. Therefore, this study highlights associations between PTMs, quantified by mass spectrometry in prefrontal cortex tissue, and Alzheimer’s disease neuropathology and cognition. Leveraging PTMs quantified from prefrontal cortic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 815c61c8-8536-5f75-8f44-f80811e044bb
DOI: 10.64898/2026.06.13.732018

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Post-translational modifications in the brain are critical contributors to Alzheimer’s disease neuropathology and cognitive declineDOI 10.64898/2026.06.13.732018Read

Mapping Post-Translational Modifications in Brain Regions in Alzheimer's Disease Using Proteomics Data MiningSemantic proximity Read

Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discoverySemantic proximity Read

Proteomic landscape of Alzheimer’s disease: emerging technologies, advances and insights (2021 – 2025)Semantic proximity Read

Compilation of reported protein changes in the brain in Alzheimer’s diseaseSemantic proximity Read

Proteomic Atlas of the Human Brain in Alzheimer’s DiseaseSemantic proximity Read

Identification of conserved proteomic networks in neurodegenerative dementiaSemantic proximity Read

Comprehensive Overview of Alzheimer’s Disease: Etiological Insights and Degradation StrategiesSemantic proximity Read

Compilation of all known protein changes in the human Alzheimer’s disease brainSemantic proximity Read

Discovery of Proteoforms Associated With Alzheimer's Disease Through Quantitative Top-Down ProteomicsSemantic proximity Read

Multi-tissue proteomic signatures of Alzheimer’s disease: a systematic investigation in brain, CSF, blood and an exploratory study in tearsSemantic proximity Read

Proteomic Signatures of Neuropathological Alterations in Alzheimer’s Disease: Insights from the Bio-Hermes StudySemantic proximity Read

Ubiquitin-Proteasome System Dysregulation in Alzheimer’s Disease Impacts Protein AbundanceSemantic proximity Read