Ubiquitin-proteasome system in the different stages of dominantly inherited Alzheimer's disease.

doi:10.1002/alz.70243

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Article

Ubiquitin-proteasome system in the different stages of dominantly inherited Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2025

Liu Haiyan, Bui Quoc, Hassenstab Jason, Gordon Brian A, Benzinger Tammie L S, Timsina Jigyasha, Sung Yun Ju, Karch Celeste, Renton Alan E, Daniels Alisha, Morris John C, Xiong Chengjie, Ibanez Laura, Perrin Richard J, Llibre-Guerra Jorge J, Day Gregory S, Supnet-Bell Charlene, Xu Xiong, Berman Sarah B, Chhatwal Jasmeer P, Ikeuchi Takeshi, Kasuga Kensaku, Niimi Yoshiki, Huey Edward D, Schofield Peter R, Brooks William S, Ryan Natalie S, Jucker Mathias, Laske Christoph, Levin Johannes, Vöglein Jonathan, Roh Jee Hoon, Lopera Francisco, Bateman Randall J, Cruchaga Carlos, McDade Eric M

Abstract excerpt

INTRODUCTION: This study investigated the role of the ubiquitin-proteasome system (UPS) in dominantly inherited Alzheimer's disease (DIAD) by examining cerebrospinal fluid (CSF) levels of UPS proteins. METHOD: The SOMAscan assay was used to detect changes in UPS proteins in mutation carriers (MCs) relative to disease progression; imaging and CSF biomarkers of amyloid, tau, and neurodegeneration measures; and...

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PMID: 40411302
DOI: 10.1002/alz.70243
PMCID: PMC12102666

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